EMAP

Research on Drugs in Primary Care

EMAP's main objective is to carry out research related to the use of drugs in primary care, assessing their effectiveness, efficiency and safety. We are an interdisciplinary group with experience in conducting studies using different methodologies, mainly observational studies with Real World Data and pragmatic clinical trials with medicines and medical devices. These different approaches allow for studying drugs in conditions of usual care and real life, as well as focusing on vulnerable populations such as children, pregnancy and lactation, older people, polymedicated patients,? EMAP participates in conducting independent clinical trials through SCReN platform, national infrastructure for the development of independent research, is part of SIGMA Consortium, responsible for providing scientific evidence in pharmacoepidemiology through European databases, it is especially involved in the study of drug use during pregnancy (ConcePTION) and in pharmacovigilance of COVID-19 vaccines (VAC4EU) and participates in the Pharmacotherapeutic Harmonization program of CatSalut through the Pharmacoepidemiology Technical Office, studying the use of drugs in real conditions.

Group projects

PI: Morros Pedrós, Rosa. BEAMER "BEhavioral and Adherence Model for improving quality, health outcomes and cost-Effectiveness of healthcaRe". Funding: Universidade do Porto. Duration: 2021 - 2026

PI: Morros Pedrós, Rosa. Mild-moderate respiratory symptoms in patients with long-COVID-19: montelukast clinical trial and biological characterization (ESPERANZA COVID). Funding: Instituto de Salud Carlos III. Duration: 2022 - 2025

PI: Giner Soriano, Maria. Retrospective Longitudinal Study on Edoxaban in Patients with Non-Valvular Atrial Fibrillation in Europe. Funding: Syneos Health Consulting INC. . Duration: 2022 - 2024

PI: Giner Soriano, Maria. Rimegepant in Patients with Migraine and History of Cardiovascular Disease in European Countries. Funding: Research Triangle Institute - USA. Duration: 2022 - 2024

PI: Moragas Moreno, Ana. Maneig de les ITUS a Catalunya: estudi descriptiu del maneig diagnòstic i terapèutic, i l'impacte de les teràpies supressores en la gravetat d'infeccions potencialment greus [Estudi ITUCAT]. Funding: Departament de Salut. Duration: 2022 - 2024

PI: Marzo Castillejo, Maria Mercè. Avaluació de la capacitat de l'Atenció Primària per a identificar i impulsar la participació de la població de risc en el cribratge de càncer de pulmó. Funding: Departament de Salut. Duration: 2022 - 2024

PI: Vedia Urgell, Cristina. Uso de fármacos en mujeres embarazadas y lactantes. Consecuencias en la salud de estas mujeres y en la de su descendencia.. Funding: Departament de Salut. Duration: 2022 - 2024

PI: Llor Vilà, Carles. IMproving Antibiotic prescribinG In NursIng homEs in Spain. A before and after intervention study (IMAGINE Study). Funding: Pfizer Inc.. Duration: 2022 - 2024

PI: Llor Vilà, Carles. Improving antibiotic use in long term care facilities by infection prevention and control and antibiotic stewardship. Funding: European Commission. Duration: 2022 - 2024

PI: Llor Vilà, Carles. Improving antibiotic use in long term care facilities by infection prevention and control and antibiotic stewardship. Funding: European Commission. Duration: 2022 - 2024

PI: Giner Soriano, Maria. Utilització de fàrmacs Insuficiència Cardíaca. Funding: IDIAP Jordi Gol. Duration: 2022 - 2024

PI: Llor Vilà, Carles. Efectividad clínica y erradicación bacteriológica de 4 pautas antibióticas cortas en infecciones urinarias en mujeres adultas. estudio SCOUT. Funding: Instituto de Salud Carlos III. Duration: 2021 - 2024

PI: Giner Soriano, Maria. Post-Authorisation Safety Study of AZD1222. A post-authorisation/post-marketing observational study to evaluate the association between exposure to AZD1222 and safety concerns using existing secondary health data sources. Funding: Research Triangle Institute. Duration: 2021 - 2024

PI: Llor Vilà, Carles. Health Alliance for Prudent Prescription and Yield of Antibiotics in a Patient-centred Perspective - Happy Patient. Funding: European Commission. Duration: 2021 - 2023

PI: Giner Soriano, Maria. Estudi de resultats en salut en diabetis mellitus tipus 2. Funding: IDIAP Jordi Gol. Duration: 2021 - 2023

PI: Monteagudo Zaragoza, Mònica. Population-based study of the effectiveness of combined LAMA / LABA versus LABA / ICS therapy as maintenance treatment in COPD patients in primary care.. Funding: Boehringer Ingelheim España, S.A.. Duration: 2021 - 2023

PI: Monteagudo Zaragoza, Mònica. Incidencia y factores de riesgo de la Covid-19 en pacientes respiratorios crónicos. Funding: IDIAP Jordi Gol. Duration: 2021 - 2023

PI: Mera Cordero, Francisco. Mild-moderate respiratory symptoms in patients with long-COVID-19: biological characterization and response to montelukast (E-SPERANZA COVID). Funding: ICS - Institut Català de la Salut. Duration: 2021 - 2023

PI: Giner Soriano, Maria. Paxlovid Non-interventional post authorization safety study (NI-PASS) Program Feasibility & Protocol Development and Regulatory Support. Funding: Research Triangle Institute. Duration: 2022 - 2022

PI: Llor Vilà, Carles. Platform randomised controlled trial of point of care diagnostics for enhancing the quality of antibiotic prescribing for community acquired acute respiratory tract infection in ambulatory care in Europe (PRUDENCE). Funding: University of Oxford. Duration: 2021 - 2022

PI: Gómez Lumbreras, Ainhoa. Safety of medication use in pregnancy and breastfeeding: Demonstrating use of secondary data sources across Europe to study medications in pregnant women using the ConcePTION platform. Funding: UMC Utrecht (University Medical Center Utrecht). Duration: 2020 - 2022

PI: Morros Pedrós, Rosa. Características sociodemográficas, clínicas y farmacológicas asociadas con el pronóstico en pacientes con infección por SARS-CoV-2.. Funding: IDIAP Jordi Gol. Duration: 2020 - 2022

PI: Llor Vilà, Carles. Effectiveness and cost-effectiveness of Improving clinicians' diagnostic and communication Skills on Antibiotic prescribing Appropriateness in patients with acute Cough in primary care in CATalonia. Funding: Fundacio La Marato de TV3. Duration: 2019 - 2022

PI: Morros Pedrós, Rosa. Evaluation of the effectiveness of pregnancy prevention programme (PPP) for oral retinoids (acitretin, alitreinoin, and isotretionoin): a European before-after drug utilization study (DUS) using secondary data. Funding: IQVIA Technology and Services AG. Duration: 2019 - 2022

PI: Ponjoan Thans, Anna. Smart City Observatories implement REsilient Water Management. Funding: Fundació Institut Català de Recerca de l'Aigua (ICRA). Duration: 2019 - 2022

PI: Llor Vilà, Carles. Intervention Study - Effectiveness and cost-effectiveness of Improving clinicians' diagnostic and communication Skills on Antibiotic prescribing Appropriateness in patients with acute Cough in primary care in CATalonia.. Funding: ICS - Institut Català de la Salut. Duration: 2019 - 2022

PI: Morros Pedrós, Rosa. Uso de la Medicación psicotrópica en niños y adolescentes en Cataluña. Estudio de cohortes 2007-2017 con real world data procedentes de la historia electrónica de atención primaria.. Funding: Departament de Salut. Duration: 2018 - 2022

The group participates in the following projects

PI: Ramos Blanes, Rafel. Programa de prevenció de malalties cardiovasculars basat en el cribratge d'arteriopatia perifèrica asimptomàtica. [Health program for prEvention of cardiovascuLar disEases based on a risk screeNing strategy with Ankle-brachial index]. HELENA Study. Funding: Departament de Salut. Duration: 2022 - 2024

PI: Vallès Fernández, Roser. Projecte implantació de la Unitat d'Enllaç Centralitzada de Vacunació antiCOVID19 (UECeV) de la DAP Metropolitana Nord. Funding: ICS - Institut Català de la Salut. Duration: 2022 - 2024

PI: Palacín Peruga, José María. Caracteristicas clinicas y ecografias asociadas con el pronostico en pacientes con pneumonia por SARS-COV-2. (PROYECTO E-COVID). Funding: IDIAP Jordi Gol. Duration: 2021 - 2024

PI: Violán Fors, Concepció. Professionals, health care workers healthy and infected with SARS-CoV2 long-term incidence, reinfection, serological protection and impact of vaccination: The ProHEpiC-19+ Cohort study. Funding: ICS - Institut Català de la Salut. Duration: 2021 - 2024

PI: Llor Vilà, Carles. Community acquired acute respiratory tract infection (CA-ARTI) in community care in Europe: point prevalence audit study (PPAS) of presentation and management. Funding: University of Oxford. Duration: 2019 - 2024

PI: Rubio Valera, Maria. Avaluació de l'efectivitat i cost-efectivitat de la intervenció d'Adherència Inicial a la Medicació (IMA): Assaig controlat aleatoritzat per conglomerats i model econòmic (IMA-cRCT). Funding: Fundació per a la recerca i la docència Sant Joan de Déu (FSJD). Duration: 2021 - 2023

PI: - -, IP no primaria. Prospective study to establish the immune status in the elderly after receiving a full course of vaccination. ENE-COVID SENIOR. Funding: ICS - Institut Català de la Salut. Duration: 2021 - 2023

Group Publications

Barrecheguren M, Monteagudo M, Miravitlles M, Flor X, Núñez A, Osorio J, Muñoz X, Ojanguren I. Characteristics and treatment patterns of patients with asthma on multiple-inhaler triple therapy in Spain. NPJ Prim Care Respir Med. 2022 03; 32(1):11. doi:10.1038/s41533-022-00270-2. Epub 2022 Mar 10. pmc:PMC8913688. PMID:35273167. IF: .

Bjerrum A, García-Sangenís A, Modena D, Córdoba G, Bjerrum L, Chalkidou A, Lykkegaard J, Hansen MP, Søndergaard J, Nexøe J, Rebnord I, Sebjørnsen I, Jensen JN, Hansen MB, Taxis K, Lambert M, Benko R, González López-Valcárcel B, Raynal F, Barragán N, Touboul P, Bruno P, Radzeviciene R, Jaruseviciene L, Bandzaite A, Godycki-Cwirko M, Kowalczyk A, Lionis C, Karkana MN, Anastasaki M, Coleman J, Glasová H, van Agtmael M, Tattevin P, Borràs A, Llor C. Health alliance for prudent prescribing and yield of antibiotics in a patient-centred perspective (HAPPY PATIENT): a before-and-after intervention and implementation study protocol. BMC Prim Care. 2022 May; 23(1):102. doi:10.1186/s12875-022-01710-1. Epub 2022 May 02. pmc:PMC9063370. PMID:35501712. IF: .

Cid-Ruzafa J, Lacy BE, Schultze A, Duong M, Lu Y, Raluy-Callado M, Donaldson R, Weissman D, Gómez-Lumbreras A, Ouchi D, Giner-Soriano M, Morros R, Ukah A, Pohl D. Linaclotide utilization and potential for off-label use and misuse in three European countries. Therap Adv Gastroenterol. 2022 ; 15:17562848221100946. doi:10.1177/17562848221100946. Epub 2022 Jun 11. pmc:PMC9189524. PMID:35706826. IF: 4,409.

Flor-Escriche X, Sanz Bas A, Álvarez Álvarez S, Zamora Putin V, Monteagudo Zaragoza M; Grupo del estudio MUNBA. [Risks, phenotypes and comparison between treatments according to guidelines GOLD and GesEPOC in primary care]. Semergen. 2022 ; 48(8):101839. doi:10.1016/j.semerg.2022.101839. Epub 2022 Oct 03. Spanish. PMID:36201965. IF: .

Giner-Soriano M, de Dios V, Ouchi D, Vilaplana-Carnerero C, Monteagudo M, Morros R. Outcomes of the COVID-19 infection in people previously vaccinated against influenza: a population-based cohort study with primary health care electronic records. JMIR Public Health Surveill. 2022 Oct; doi:10.2196/36712. Epub 2022 Oct 18. PMID:36265160. IF: 4,112.

Giner-Soriano M, Díaz Baena D, Ouchi D, Gomez-Lumbreras A, Morros R. [Pharmacological treatment of the heart failure according to the ventricular ejection fraction in primary care]. Aten Primaria. 2022 Jun; 54(8):102362. doi:10.1016/j.aprim.2022.102362. Epub 2022 Jun 28. Spanish. PMID:35777241. IF: 1,137.

Giner-Soriano M, Gomez-Lumbreras A, Vedia C, Ouchi D, Morros R. Risk of thrombotic events and other complications in anticoagulant users infected with SARS-CoV-2: an observational cohort study in primary health care in SIDIAP (Catalonia, Spain). BMC Prim Care. 2022 Jun; 23(1):147. doi:10.1186/s12875-022-01752-5. Epub 2022 Jun 08. PMID:35676639. IF: .

Llor C, Moragas A, Aguilar-Sánchez M, García-Sangenís A, Monfà R, Morros R. Best methods for urine sample collection for diagnostic accuracy in women with urinary tract infection symptoms: a systematic review. Fam Pract. 2022 Jun; doi:10.1093/fampra/cmac058. Epub 2022 Jun 02. PMID:35652481. IF: 2,267.

Llor C, Moragas A, Ouchi D, Monfà R, Garcia-Sangenís A, Gómez-Lumbreras A, Pera H, Pujol J, Morros R. Effectiveness of antitussives, anticholinergics, and honey versus usual care in adults with uncomplicated acute bronchitis: a multiarm randomized clinical trial. Fam Pract. 2022 Oct; doi:10.1093/fampra/cmac112. Epub 2022 Oct 14. pmc:PMC9619792. PMID:36239199. IF: 2,267.

Mera-Cordero F, Bonet-Monne S, Almeda-Ortega J, García-Sangenís A, Cunillera-Puèrtolas O, Contreras-Martos S, Alvarez-Muñoz G, Monfà R, Balanzó-Joué M, Morros R, Salvador-Gonzalez B. Correction to: Double-blind placebo-controlled randomized clinical trial to assess the efficacy of montelukast in mild to moderate respiratory symptoms of patients with long COVID: E-SPERANZA COVID Project study protocol. Trials. 2022 Feb; 23(1):130. doi:10.1186/s13063-022-06073-7. Epub 2022 Feb 09. pmc:PMC8827194. PMID:35139906. IF: .

Mera-Cordero F, Bonet-Monne S, Almeda-Ortega J, García-Sangenís A, Cunillera-Puèrtolas O, Contreras-Martos S, Alvarez-Muñoz G, Monfà R, Balanzo-Joué M, Morros R, Salvador-Gonzalez B. Double-blind placebo-controlled randomized clinical trial to assess the efficacy of montelukast in mild to moderate respiratory symptoms of patients with long COVID: E-SPERANZA COVID Project study protocol. Trials. 2022 Jan; 23(1):19. doi:10.1186/s13063-021-05951-w. Epub 2022 Jan 06. pmc:PMC8733792. PMID:34991703. IF: .

Monteagudo M, Nuñez A, Barrecheguren M, Miravitlles M. Effectiveness of Treatment With Dual Bronchodilation (LABA/LAMA) Compared With Combination Therapy (LABA/ICS) for Patients With COPD: A Population-Based Study. Arch Bronconeumol. 2022 May; doi:10.1016/j.arbres.2022.05.002. Epub 2022 May 13. PMID:35618580. IF: 4,872.

Ouchi D, Giner-Soriano M, Gómez-Lumbreras A, Vedia Urgell C, Torres F, Morros R. Automatic Estimation of the Most Likely Drug Combination in Electronic Health Records Using the Smooth Algorithm: Development and Validation Study. JMIR Med Inform. 2022 Nov; 10(11):e37976. doi:10.2196/37976. Epub 2022 Nov 15. PMID:36378514. IF: .

Ouchi D, Vilaplana-Carnerero C, de Dios V, Giner-Soriano M, Morros R. Antidiabetic treatment and COVID-19 Outcomes: A population-based cohort study in primary health care in Catalonia during the first wave of the pandemic. Prim Care Diabetes. 2022 Oct; doi:10.1016/j.pcd.2022.10.001. Epub 2022 Oct 04. pmc:PMC9531669. PMID:36216752. IF: 2,459.

van der Velden AW, van de Pol AC, Bongard E, Cianci D, Aabenhus R, Balan A, Böhmer F, Brali? Lang V, Bruno P, Chlabicz S, Coenen S, Colliers A, García-Sangenís A, Ghazaryan H, Godycki-?wirko M, Jensen S, Lionis C, van der Linde SR, Malania L, Pauer J, Tomacinschii A, Vellinga A, Zastavnyy I, Emmerich S, Zerda A, Verheij TJ, Goossens H, Butler CC. Point-of-care testing, antibiotic prescribing, and prescribing confidence for respiratory tract infections in primary care: a prospective audit in 18 European countries. BJGP Open. 2022 Apr; doi:10.3399/BJGPO.2021.0212. Epub 2022 Apr 06. PMID:34920989. IF: .

Villén N, Roso-Llorach A, Gallego-Moll C, Danes-Castells M, Fernández-Bertolin S, Troncoso-Mariño A, Monteagudo M, Amado E, Violán C. Polypharmacy Patterns in Multimorbid Older People with Cardiovascular Disease: Longitudinal Study. Geriatrics (Basel). 2022 Dec; 7(6). doi:10.3390/geriatrics7060141. Epub 2022 Dec 13. pmc:PMC9777651. PMID:36547277. IF: .

Vona-Giralt G, Vilaplana-Carnerero C, Ouchi D, Gomez-Lumbreras A, Morros R, Giner-Soriano M. Risk of psychiatric events in women treated with isotretinoin: a self-controlled study with SIDIAP database. Expert Opin Drug Saf. 2022 Sep; doi:10.1080/14740338.2022.2120608. Epub 2022 Sep 05. PMID:36045482. IF: 4,250.

The group participates in the following publications

Rey-Reñones C, Martinez-Torres S, Martín-Luján FM, Pericas C, Redondo A, Vilaplana-Carnerero C, Dominguez A, Grau M. Type 2 Diabetes Mellitus and COVID-19: A Narrative Review. Biomedicines. 2022 Aug; 10(9). doi:10.3390/biomedicines10092089. Epub 2022 Aug 26. pmc:PMC9495673. PMID:36140191. IF: .

Violán C, Torán-Monserrat P, Quirant B, Lamonja-Vicente N, Carrasco-Ribelles LA, Chacón C, Manresa-Dominguez JM, Ramos-Roure F, Dacosta-Aguayo R, Palacios-Fernández C, Roso-Llorach A, Pujol A, Ouchi D, Monteagudo M, Montero-Alia P, Garcia-Sierra R, Arméstar F, Doladé M, Prat N, Bonet JM, Clotet B, Blanco I, Boigues-Pons M, Moreno-Millán N, Prado JG, Cáceres EMM; ProHEpiC-19 study. Kinetics of humoral immune response over 17?months of COVID-19 pandemic in a large cohort of healthcare workers in Spain: the ProHEpiC-19 study. BMC Infect Dis. 2022 Sep; 22(1):721. doi:10.1186/s12879-022-07696-6. Epub 2022 Sep 03. PMID:36057544. IF: .


Indicators

Indicator

2022

Researchers with PhD

5

Total number of projects in which group members have participated

44

Total number of projects in which the PI of the project has belonged to the group

16

Total Funding

3.129.454,31€

Scientific publications in indexed journals

8

Total Impact factor

25,77

Nº of articles in Q1 journals

1

Q1 IF

4,112

Nº of articles in Q2 journals

3

Q2 IF

13,531
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